Publications

Function and Regulation of Sleep

2025

FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila

Keleş, M.F., Sapci, A.O.B., Brody, C., Palmer, I., Mehta, A., Ahmadi, S., Le, C., Taştan, Ö., Keleş, S., and Wu, M.N. (2025). FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila. Sci. Adv. 11, eadq8131.

2023

A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus

Liu, Q., Bell, B. J., Kim, D. W., Lee, S. S., Keles, M. F., Liu, Q., Blum, I. D., Wang, A. A., Blank, E. J., Xiong, J., Bedont, J. L., Chang, A. J., Issa, H., Cohen, J. Y., Blackshaw, S., & Wu, M. N. (2023). A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus. Nature Communications, 14(1), 6381.

A subclass of evening cells promotes the switch from arousal to sleep at dusk

Brown, M. P., Verma, S., Palmer, I., Guerrero Zuniga, A., Mehta, A., Rosensweig, C., Keles, M. F., & Wu, M. N. (2024). Current Biology: CB, 34(10), 2186–2199.e3. https://doi.org/10.1016/j.cub.2024.04.039

2021

Astroglial Calcium Signaling Encodes Sleep Need in Drosophila

Blum, I. D.*, Keleş, M. F.*, Baz, E.-S., Han, E., Park, K., Luu, S., Issa, H., Brown, M., Ho, M. C. W., Tabuchi, M., Liu, S., & Wu, M. N. (2021). Current Biology: CB, 31(1), 150–162.e7. *equal contributions

Visual Feature Detection

2021

A visual pathway for skylight polarization processing in Drosophila

Hardcastle, B. J., Omoto, J. J., Kandimalla, P., Nguyen, B.-C. M., Keleş, M. F., Boyd, N. K., Hartenstein, V., & Frye, M. A. (2021). eLife, 10.

2020

Non-canonical Receptive Field Properties and Neuromodulation of Feature-Detecting Neurons in Flies

Städele, C., Keleş, M. F., Mongeau, J.-M., & Frye, M. A. (2020). Current Biology: CB, 30(13), 2508–2519.e6.

Inhibitory Interactions and Columnar Inputs to an Object Motion Detector in Drosophila

Keleş, M. F.*, Hardcastle, B. J.*, Städele, C., Xiao, Q., & Frye, M. A. (2020). Cell Reports, 30(7), 2115–2124.e5. *equal contributions

2019

Object features and T4/T5 motion detectors modulate the dynamics of bar tracking by Drosophila

Keleş, M. F., Mongeau, J.-M., & Frye, M. A. (2019). The Journal of Experimental Biology, 222(Pt 2).

Cell-type-Specific Patterned Stimulus-Independent Neuronal Activity in the Drosophila Visual System during Synapse Formation

Akin, O., Bajar, B. T., Keles, M. F., Frye, M. A., & Zipursky, S. L. (2019). Cell-type-Specific Patterned Stimulus-Independent Neuronal Activity in the Drosophila Visual System during Synapse Formation. Neuron, 101(5), 894–904.e5.

2017

Visual Input to the Drosophila Central Complex by Developmentally and Functionally Distinct Neuronal Populations

Omoto, J. J.*, Keleş, M. F.*, Nguyen, B.-C. M., Bolanos, C., Lovick, J. K., Frye, M. A., & Hartenstein, V. (2017). Current Biology: CB, 27(8), 1098–1110. *equal contributions

Object-Detecting Neurons in Drosophila

Keleş, M. F., & Frye, M. A. (2017). Current Biology: CB, 27(5), 680–687.

2015

Neurons forming optic glomeruli compute figure–ground discriminations in Drosophila

Aptekar, J. W., Keleş, M. F., Lu, P. M., Zolotova, N. M., & Frye, M. A. (2015). The Journal of Neuroscience, 35(19), 7587–7599.

Olfactory neuromodulation of motion vision circuitry in Drosophila

Wasserman, S. M., Aptekar, J. W., Lu, P., Nguyen, J., Wang, A. L., Keles, M. F., Grygoruk, A., Krantz, D. E., Larsen, C., & Frye, M. A. (2015). Current Biology: CB, 25(4), 467–472.

2014

Method and software for using m-sequences to characterize parallel components of higher-order visual tracking behavior in Drosophila

Aptekar, J. W., Keles, M. F., Mongeau, J.-M., Lu, P. M., Frye, M. A., & Shoemaker, P. A. (2014). Frontiers in Neural Circuits, 8, 130.

Other

2014

GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons

Ho, V. M., Dallalzadeh, L. O., Karathanasis, N., Keles, M. F., Vangala, S., Grogan, T., Poirazi, P., & Martin, K. C. (2014). Molecular and Cellular Neurosciences, 61, 1–12.